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胎盘生长因子抗体
  • 产品货号：
    BN41516R
  • 中文名称：
    胎盘生长因子抗体
  • 英文名称：
    Rabbit anti-PLGF Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41516R-50ul

    50ul

    ¥1486.00

    交叉反应：Human(predicted:Mouse) 推荐应用：WB,ELISA

  • BN41516R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse) 推荐应用：WB,ELISA

  • BN41516R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse) 推荐应用：WB,ELISA

英文名称PLGF
中文名称胎盘生长因子抗体
别    名Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.  
研究领域肿瘤  心血管  生长因子和激素  血管内皮细胞  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse PLGF:131-158/158 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor. Alternative splicing of the PIGF primary transcript gives rise to two forms, named PIGF-1 and PIGF-2, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions. However, the role of PIGF in vascular development has not yet been clearly established.

Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF (By similarity).

Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P49763

Gene ID:
18654

Database links:

Entrez Gene: 5228 Human

Entrez Gene: 18654 Mouse

Omim: 601121 Human

SwissProt: P49763 Human

SwissProt: P49764 Mouse

Unigene: 252820 Human

Unigene: 4809 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PLGF胎盘生长因子是血管生长因子家族成员之一，是动脉粥样硬化斑块不稳定的主要炎性激活物，因此它可作为ACS患者风险预测的生物学标志物.尿胎盘生长因子水平可预测先兆子痫危险.研究人员发现，在疾病发作前的6到8周，先兆子痫患者尿液中的胎盘生长因子水平急剧下降,这种新的尿检方法使提前1到2个月预测先兆子痫成为可能。亦有研究人员正在从事胎盘生长因子与肺气肿，胃癌，肠癌等方面的研究。


















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