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BN41491R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41491R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41491R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
| 英文名称 | FLIP |
| 中文名称 | 凋亡调节基因之一抗体 |
| 别 名 | CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p43; Flice-like Inhibitory protein; c FLIP; c FLIPL; c FLIPR; c FLIPS; c-FLIP; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD like apoptosis regulator precursor; CASP8AP1; Caspase Eight Related Protein; Caspase homolog; Caspase Homologue; Caspase Like Apoptosis Regulatory Protein; Caspase related inducer of apoptosis; CASPER; Cellular FLICE like inhibitory protein; CFLA; CFLAR; CLARP; FADD like anti apoptotic molecule; FADD Like Anti-apoptotic Molecule 1; FADD-like antiapoptotic molecule 1; FADD like antiapoptotic molecule 1; FADD Like Apoptosis Regulator; FLAME 1; FLAME; FLAME1; FLAME-1; FLICE Inhibitor Protein; FLIP; FLIPs; I FLICE; I-FLICE; Inhibitor of FLICE; Inhibitor of FLICE; MACH Related Inducer of Toxicity; MACH-related inducer of toxicity; mFLIP; MRIT; USURPIN; Usurpin beta; FLICE-like inhibitory protein short form; FLICE-like inhibitory protein long form; CFLAR_HUMAN; Cellular FLICE-like inhibitory protein. |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43/52kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CASP8 and FADD-like apoptosis regulator subunit p43:7-100/480 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011] Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. Subunit: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X. Tissue Specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle. Post-translational modifications: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12. Similarity: Belongs to the peptidase C14A family. Contains 2 DED (death effector) domains. SWISS: O15519 Gene ID: 8837 Database links: Entrez Gene: 8837 Human Entrez Gene: 12633 Mouse Omim: 603599 Human SwissProt: O15519 Human SwissProt: O35732 Mouse Unigene: 390736 Human Unigene: 336848 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FLIP参与凋亡的调节。此抗体在长型和短型的FLIP异构体中均表达。短型FLIP包含2个死亡效应基因结构区，同源于FAS相关蛋白死亡效应基因结构区。长型FLIP包含1个附加的Caspase 样结构区，但是他缺少一个催化部位和在大多数Caspase 蛋白中形成底物结合束的残基。 |
