货号
产品规格
售价
备注
BN41482R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse(predicted:Rat,Dog,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41482R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse(predicted:Rat,Dog,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41482R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse(predicted:Rat,Dog,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
| 英文名称 | Caspase-6 subunit p18 |
| 中文名称 | 半胱胺酸蛋白酶蛋白-6抗体 |
| 别 名 | Caspase-6; Caspase-6 p18; cleaved Caspase-6 p18; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN; caspase-6 isoform alpha precursor. |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, (predicted: Rat, Dog, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 18/33kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Caspase-6 subunit p18:27-130/293 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Subcellular Location: Cytoplasm. Post-translational modifications: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. Similarity: Belongs to the peptidase C14A family. SWISS: P55212 Gene ID: 839 Database links: Entrez Gene: 839 Human Entrez Gene: 12368 Mouse Omim: 601532 Human SwissProt: P55212 Human SwissProt: O08738 Mouse Unigene: 654616 Human Unigene: 281379 Mouse Unigene: 88160 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Caspase-6 与Caspase-3有38%的同源性，属胱氨酸-天冬氨酸蛋白酶家族。在凋亡执行阶段起中心作用，可被Caspase-7、-8、-10剪切。它是唯一一个可以剪切核纤层蛋白的Caspase。 |
