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P物质抗体
  • 产品货号：
    BN41477R
  • 中文名称：
    P物质抗体
  • 英文名称：
    Rabbit anti-Substance P Polyclonal antibody

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  • BN41477R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41477R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41477R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat,GuineaPig(predicted:Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

英文名称Substance P
中文名称P物质抗体
别    名Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.  


研究领域神经生物学  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量1.4/13kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Substance P(RPKPQQFFGLM):58-68/129 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Subcellular Location:
Secreted.

Similarity:
Belongs to the tachykinin family.

SWISS:
P20366

Gene ID:
6863

Database links:

Entrez Gene: 6863 Human

Entrez Gene: 21333 Mouse

Entrez Gene: 24806 Rat

Omim: 162320 Human

SwissProt: P20366 Human

SwissProt: P41539 Mouse

SwissProt: P06767 Rat

Unigene: 2563 Human

UniProtKB/Swiss-Prot: P20366.1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P物质（Substance P）是脑组织及消化道中发现的一种神经递质肽。由130个氨基酸残基组成，胃肠道中肌肉收缩的有力促进剂，亦为强血管扩张剂。
SP是一种脑肠肽，亦是最早发现的一种神经肽，属于速激肽家族成员，它广泛分布于中枢及外周神经系统，作为一种神经递质或调质参与疼痛、免疫、心血管等多种生理功能的调节。SP与其它的递质或调质类似，能作用于多种类型的受体，速激肽家族有NK1、NK2、NK3三种受体，都能与SP结合，其中NK1与SP的结合能力最强而被称为SP受体。


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