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黑色素瘤相关抗原/黑色素-A抗体
  • 产品货号：
    BN41473R
  • 中文名称：
    黑色素瘤相关抗原/黑色素-A抗体
  • 英文名称：
    Rabbit anti-Melan A Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41473R-50ul

    50ul

    ¥1486.00

    交叉反应：Human 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41473R-100ul

    100ul

    ¥2360.00

    交叉反应：Human 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41473R-200ul

    200ul

    ¥3490.00

    交叉反应：Human 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称Melan A
中文名称黑色素瘤相关抗原/黑色素-A抗体
别    名Protein Melan-A; Antigen LB39 AA; MelanA; Melanoma HMB45; Antigen SK29 AA; Antigen SK29-AA; CMM 1; CMM; CMM1; Cutaneous Malignant Melanoma Dysplastic Nevus; DNS; Dysplastic Nevus Syndrome; FAMMM; MART1; melan A; Melan A protein; Melanoma antigen recognized by T-cells 1; MLM; Monophenol monooxygenase; Tumor rejection antigen AB; tyrosinase; Melanoma HMB45; Melanoma; Melan-A; MART-1; MAR1_HUMAN.  
研究领域肿瘤  细胞生物  免疫学  肿瘤细胞生物标志物  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, 
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Melan-A:51-118/118 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis.

Function:
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Subunit:
Interacts with PMEL. Interacts with GPR143.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Tissue Specificity:
Expression is restricted to melanoma and melanocyte cell lines and retina.

Post-translational modifications:
Acylated.

SWISS:
Q16655

Gene ID:
2315

Database links:

Entrez Gene: 2315 Human

Omim: 605513 Human

SwissProt: Q16655 Human

Unigene: 154069 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信号中间体（Signaling Intermediates）
MelanA/MART-1是分化肿瘤抗原类别中具有代表性的成员，它表达于正常的黑素细胞和大多数原发及转移的黑色素瘤中，故称：黑色素瘤相关抗原。

















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