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腺嘌呤核苷酸转运蛋白1、2、3、4抗体
  • 产品货号：
    BN41394R
  • 中文名称：
    腺嘌呤核苷酸转运蛋白1、2、3、4抗体
  • 英文名称：
    Rabbit anti-ANT1+ANT2+ANT3+ANT4 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41394R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41394R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称ANT1+ANT2+ANT3+ANT4
中文名称腺嘌呤核苷酸转运蛋白1、2、3、4抗体
别    名ATP carrier protein 1; ADP ATP carrier protein heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADT1_HUMAN; ANT 1; ANT; ANT1; ATP carrier protein 2; ADP ATP carrier protein heart/skeletal muscle isoform T2; ADP/ATP translocase 2; ADT2_HUMAN; ANT 2; ANT; ATP carrier protein 3; ADP ATP carrier protein heart/skeletal muscle isoform T3; ADP/ATP translocase 3; ADT3_HUMAN; ANT3; ATP carrier protein 4; ADP ATP carrier protein heart/skeletal muscle isoform T4; ADP/ATP translocase 4; ADT4_HUMAN; ANT 4;ANT4.  
研究领域心血管  细胞生物  神经生物学  信号转导  转录调节因子  G蛋白偶联受体  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ANT1/2/3/4:51-150/298 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.

Function:
Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

Subunit:
Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer. Interacts with HIV-1 Vpr.

Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.

DISEASE:
Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2) [MIM:609283]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.

Similarity:
Belongs to the mitochondrial carrier family.

SWISS:
P12235 Q9H0C2

Gene ID:
291 83447

Database links:
UniProtKB/Swiss-Prot: P12235.4 UniProtKB/Swiss-Prot: Q9H0C2.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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