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锚定蛋白样蛋白1抗体
  • 产品货号：
    BN41379R
  • 中文名称：
    锚定蛋白样蛋白1抗体
  • 英文名称：
    Rabbit anti-ASZ1 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41379R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41379R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称ASZ1
中文名称锚定蛋白样蛋白1抗体
别    名Ankyrin repeat, SAM and basic leucine zipper domain containing protein 1; Ankyrin repeat, SAM and basic leucine zipper domain containing protein 1; ALP1; ANKL1; Ankyrin like protein 1; ASZ 1; ASZ1_HUMAN.  
研究领域肿瘤  心血管  细胞生物  神经生物学  信号转导  细胞周期蛋白  激酶和磷酸酶  细胞分化  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASZ1:151-250/475 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1), also known as ANKL1, ALP1 (Ankyrin-like protein 1), GASZ (germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) or Orf3, is a 475 amino acid protein that is suggested to function as a signal transducer during germ cell maturation. Localized to the cytoplasm of pachytene spermatocytes, early spermatids and oocytes, ASZ1 is primarily found in adult testis and ovary where it mediates protein-protein interactions. ASZ1 contains six ANK repeats, one SAM (sterile alpha motif) domain and is encoded by a gene located on human chromosome 7q31, a region that may have an important role in the development certain types of human cancer.

Function:
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

Subunit:
Interacts with DDX4, PIWIL1, RANBP9 and TDRD1 (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity).

Tissue Specificity:
Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary.

Similarity:
Contains 6 ANK repeats.
Contains 1 SAM (sterile alpha motif) domain.

SWISS:
Q8WWH4

Gene ID:
136991

Database links:

Entrez Gene: 136991 Human

SwissProt: Q8WWH4 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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