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着丝粒蛋白O抗体
  • 产品货号：
    BN41377R
  • 中文名称：
    着丝粒蛋白O抗体
  • 英文名称：
    Rabbit anti-CENPO Polyclonal antibody

  • 货号

    产品规格

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  • BN41377R-100ul

    100ul

    ¥2360.00

    交叉反应：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41377R-200ul

    200ul

    ¥3490.00

    交叉反应：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称CENPO
中文名称着丝粒蛋白O抗体
别    名CENPO binds to the kinetochore. Its depletion from cells interferes with spindle assembly. It is necessary for correct binding of spindle checkpoint proteins to kinetochores. It is required for checkpoint signaling;   
研究领域细胞生物  细胞周期蛋白  细胞分化  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CENPO:101-200/300 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍CENPO binds to the kinetochore. Its depletion from cells interferes with spindle assembly. It is necessary for correct binding of spindle checkpoint proteins to kinetochores. It is required for checkpoint signaling.

Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Subunit:
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU.

Subcellular Location:
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

SWISS:
Q9BU64

Gene ID:
79172

Database links:

Entrez Gene: 79172 Human

Entrez Gene: 52504 Mouse

Omim: 611504 Human

SwissProt: Q9BU64 Human

SwissProt: Q8K015 Mouse

Unigene: 731569 Human

Unigene: 70546 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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