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中间丝相关蛋白抗体
  • 产品货号：
    BN41369R
  • 中文名称：
    中间丝相关蛋白抗体
  • 英文名称：
    Rabbit anti-Repetin Polyclonal antibody

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    产品规格

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  • BN41369R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Horse,Cow,Pig,Rat,Mouse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41369R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Horse,Cow,Pig,Rat,Mouse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称Repetin
中文名称中间丝相关蛋白抗体
别    名Intermediate filament associated protein; RPTN; RPTN_HUMAN.  
研究领域细胞生物  信号转导  细胞周期蛋白  细胞分化  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量91kDa
细胞定位细胞外基质 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Repetin:41-140/784 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Repetin is a 784 amino acid secreted protein that belongs to the S100-fused protein family. Repetin is an extracellular epidermal matrix protein that is expressed in the epidermis and at high levels in eccrine sweat glands, the inner sheaths of hair roots and the filiform papilli of the tongue. A multifunctional epidermal matrix protein, repetin is involved in the cornified cell envelope formation. Containing two EF-hand domains, repetin’s recombinant N-terminal domain binds calcium reversibly. Repetin and trichohyalin may compensate for absent loricrin. The repetin gene contains three exons, two introns and spans at least 5.6 kb. The repetin gene is conserved in cow, mouse and rat, and maps to human chromosome 1q21.3.

Function:
Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Repetin is a multifunctional epidermal matrix protein involved in the cornified cell envelope formation. It reversibly binds calcium. Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.

Post-translational modifications:
Potential substrate of transglutaminase. Some arginines are probably converted.
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.

SWISS:
Q6XPR3

Gene ID:
126638

Database links:

Entrez Gene: 126638 Human

Entrez Gene: 20129 Mouse

Omim: 613259 Human

SwissProt: Q6XPR3 Human

SwissProt: P97347 Mouse

Unigene: 376144 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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