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LRRC59蛋白抗体
  • 产品货号：
    BN41318R
  • 中文名称：
    LRRC59蛋白抗体
  • 英文名称：
    Rabbit anti-LRRC59 Polyclonal antibody

  • 货号

    产品规格

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  • BN41318R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41318R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称LRRC59
中文名称LRRC59蛋白抗体
别    名Leucine-rich repeat-containing protein 59; LRC59_HUMAN; LRRC59; PRO1855.  
研究领域细胞生物  免疫学  信号转导  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
细胞定位细胞核 细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LRRC59:21-120/307 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍LRRC59 (leucine rich repeat containing 59), also known as PRO1855, is a 307 amino acid protein that contains leucine-rich repeats and may play a role in protein binding events throughout the cell. The gene encoding LRRC59 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Subunit:
Can form homodimers. Interacts with SGOL1. Interacts with FGF1.

Subcellular Location:
Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Tissue Specificity:
Widely expressed.

Similarity:
Contains 5 LRR (leucine-rich) repeats.

SWISS:
Q96AG4

Gene ID:
55379

Database links:

Entrez Gene: 55379 Human

Entrez Gene: 98238 Mouse

Omim: 614854 Human

SwissProt: Q96AG4 Human

SwissProt: Q922Q8 Mouse

Unigene: 370927 Human

Unigene: 172720 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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