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BN41316R-100ul
100ul
¥2360.00
交叉反应：Human(predicted:Mouse,Rat,Pig,Cow) 推荐应用：WB,Flow-Cyt,ELISA
BN41316R-200ul
200ul
¥3490.00
交叉反应：Human(predicted:Mouse,Rat,Pig,Cow) 推荐应用：WB,Flow-Cyt,ELISA
| 英文名称 | LYL1 |
| 中文名称 | 淋巴细胞性白血病相关序列1抗体 |
| 别 名 | Lyl1; Lymphoblastic leukemia derived sequence 1; Protein lyl 1. |
| 研究领域 | 肿瘤 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Pig, Cow, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LYL1:151-250/280 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The Lyl1 gene encodes a basic helix–loop–helix transcription factor involved in T-cell acute lymphoblastic leukemia. The expression of Lyl1 is at higher levels in the majority of cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. Lyl1 is highly expressed in most AML cell lines.Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor ∫ chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2å proteins. Lyl-1 and E2å protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL). Function: Efficient DNA binding requires dimerization with another bHLH protein. Subcellular Location: Nucleus (Potential). DISEASE: Note=A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: P12980 Gene ID: 4066 Database links: Entrez Gene: 4066 Human Entrez Gene: 17095 Mouse Omim: 151440 Human SwissProt: P12980 Human SwissProt: P27792 Mouse Unigene: 46446 Human Unigene: 728534 Human Unigene: 4925 Mouse Unigene: 17352 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
