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染色体结构维持蛋白6抗体
  • 产品货号：
    BN41268R
  • 中文名称：
    染色体结构维持蛋白6抗体
  • 英文名称：
    Rabbit anti-SMC6 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41268R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41268R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称SMC6
中文名称染色体结构维持蛋白6抗体
别    名SMC6L1; SMC 6; SMC6; SMC6 protein; SMC6 structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes 6; Structural maintenance of chromosomes 6 like 1; Structural maintenance of chromosomes protein 6.  
研究领域细胞生物  细胞周期蛋白  细胞分化  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量126 kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SMC6:155-260/1091 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells.

Function:
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.

Subunit:
Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed. Overexpressed in testis.

Post-translational modifications:
Ubiquitinated.

Similarity:
Belongs to the SMC family. SMC6 subfamily.

SWISS:
Q96SB8

Gene ID:
79677

Database links:
UniProtKB/Swiss-Prot: Q96SB8.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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