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内质网核信号转导蛋白2抗体
  • 产品货号：
    BN41233R
  • 中文名称：
    内质网核信号转导蛋白2抗体
  • 英文名称：
    Rabbit anti-ERN2 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41233R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推荐应用：Flow-Cyt,ELISA

  • BN41233R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推荐应用：Flow-Cyt,ELISA

英文名称ERN2
中文名称内质网核信号转导蛋白2抗体
别    名IRE1b; Endoplasmic reticulum to nucleus signaling 2; ER to nucleus signalling 2; ERN 2; Ern1; hIRE2p; Inositol requiring 1 beta; Inositol requiring protein 2; Ire1; Ire1 beta; IRE1 S. cerevisiae homolog of; IRE2; Serine/threonine protein kinase/endoribonuclease IRE2; ERN2_HUMAN.  
研究领域细胞生物  信号转导  细胞凋亡  转录调节因子  激酶和磷酸酶  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Sheep, )
产品应用ELISA=1:5000-10000 Flow-Cyt=2ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量98kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ERN2:465-550/926 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍ERN2, endoplasmic reticulum to nucleus signaling 2, induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. It is pro-apoptotic and appears to play no role in the unfolded-protein response, unlike closely related proteins.

Function:
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain.

SWISS:
O75460

Gene ID:
10595

Database links:

Entrez Gene: 10595 Human

Entrez Gene: 26918 Mouse

Omim: 604034 Human

SwissProt: O75460 Human

SwissProt: Q9EQY0 Mouse

Unigene: 133982 Human

Unigene: 20452 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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