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候选肿瘤抑制基因MARVELD1抗体
  • 产品货号：
    BN41217R
  • 中文名称：
    候选肿瘤抑制基因MARVELD1抗体
  • 英文名称：
    Rabbit anti-MARVELD1 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41217R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41217R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称MARVELD1
中文名称候选肿瘤抑制基因MARVELD1抗体
别    名GB14; MARVD1; MARVEL (membrane-associating) domain containing 1; MARVEL domain containing protein 1; MRVLDC1; Putative MARVEL domain containing protein 1; MALD1_HUMAN.  
研究领域肿瘤  肿瘤细胞生物标志物  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位细胞核 细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MARVELD1:31-130/173 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.

Function:
Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization.

Tissue Specificity:
Widely expressed in normal tissues. Down-regulated in multiple primary tumors.

Similarity:
Contains 1 MARVEL domain.

SWISS:
Q9BSK0

Gene ID:
83742

Database links:

Entrez Gene: 83742 Human

Entrez Gene: 277010 Mouse

Entrez Gene: 309375 Rat

SwissProt: Q9BSK0 Human

SwissProt: Q7TQJ1 Mouse

Unigene: 209614 Human

Unigene: 206250 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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