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睾丸酸性磷酸酶抗体
  • 产品货号：
    BN41208R
  • 中文名称：
    睾丸酸性磷酸酶抗体
  • 英文名称：
    Rabbit anti-ACPT Polyclonal antibody

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  • BN41208R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41208R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称ACPT
中文名称睾丸酸性磷酸酶抗体
别    名Acid phosphatase testicular; Testicular acid phosphatase; PPAT_HUMAN.  
研究领域肿瘤  细胞生物  信号转导  生长因子和激素  转录调节因子  肿瘤细胞生物标志物  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ACPT:65-160/437 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is upregulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. ACPT dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. ACPT is predominantly expressed in testis but exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Potential).

Tissue Specificity:
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.

SWISS:
Q9BZG2

Gene ID:
93650

Database links:

Entrez Gene: 93650 Human

Omim: 606362 Human

SwissProt: Q9BZG2 Human

Unigene: 293394 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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