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丝氨酸/苏氨酸蛋白激酶38抗体
  • 产品货号：
    BN41205R
  • 中文名称：
    丝氨酸/苏氨酸蛋白激酶38抗体
  • 英文名称：
    Rabbit anti-STK38 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41205R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41205R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,GuineaPig) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称STK38
中文名称丝氨酸/苏氨酸蛋白激酶38抗体
别    名NDR 1; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; Serine/threonine protein kinase 38; STK 38; STK-38; STK38_HUMAN.  
研究领域肿瘤  细胞生物  免疫学  信号转导  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human STK38:31-130/465 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38.

Function:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2.

Subunit:
Homodimeric S100B binds two molecules of STK38.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Post-translational modifications:
ISGylated (Probable).
Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

SWISS:
Q15208

Gene ID:
11329

Database links:

Entrez Gene: 11329 Human

Entrez Gene: 106504 Mouse

Omim: 606964 Human

SwissProt: Q15208 Human

SwissProt: Q91VJ4 Mouse

Unigene: 409578 Human

Unigene: 439986 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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