首页>>蛋白研究>>抗体>>丝氨酸/苏氨酸特定蛋白磷酸酶抗体
丝氨酸/苏氨酸特定蛋白磷酸酶抗体
  • 产品货号：
    BN41204R
  • 中文名称：
    丝氨酸/苏氨酸特定蛋白磷酸酶抗体
  • 英文名称：
    Rabbit anti-DUSP3 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41204R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41204R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称DUSP3
中文名称丝氨酸/苏氨酸特定蛋白磷酸酶抗体
别    名Dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3_HUMAN; DUSP3; Serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; Vaccinia virus phosphatase VH1 related; VHR.  
研究领域肿瘤  信号转导  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human VHR/DUSP3:41-140/185 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Function:
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Subunit:
Interacts with VRK3, which seems to activate it's phosphatase activity

Subcellular Location:
Nucleus.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.

SWISS:
P51452

Gene ID:
1845

Database links:

Entrez Gene: 1845 Human

Entrez Gene: 72349 Mouse

Entrez Gene: 498003 Rat

GenBank: NP_004081.1 Human

Omim: 600183 Human

SwissProt: P51452 Human

SwissProt: Q9D7X3 Mouse

Unigene: 181046 Human

Unigene: 196295 Mouse

Unigene: 8286 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















image.png