G蛋白α亚单位蛋白Q抗体

产品货号：

BN41193R
中文名称：

G蛋白α亚单位蛋白Q抗体
英文名称：

Rabbit anti-GNAQ Polyclonal antibody

货号

产品规格

售价

备注
BN41193R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA
BN41193R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称	GNAQ
中文名称	G蛋白α亚单位蛋白Q抗体
别名	G ALPHA q; G protein alpha Q; GAQ; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G q subunit alpha; GNAQ_HUMAN.
研究领域	肿瘤心血管细胞生物神经生物学信号转导 G蛋白偶联受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞核细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GNAQ:51-150/359
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	GNAQ belong to the family of heterotrimeric Guanine nucleotide-binding proteins proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. GNAQ is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta. in recent studies over expression of GNAQ is associated with cardiomyocyte apoptosis. Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1. Subcellular Location: Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). Tissue Specificity: Predominantly expressed in ovary, prostate, testis and colon. Similarity: Belongs to the G-alpha family. G(q) subfamily. SWISS: P50148 Gene ID: 2776 Database links: Entrez Gene: 2776 Human Entrez Gene: 14682 Mouse Entrez Gene: 654405 Pig Entrez Gene: 81666 Rat Omim: 600998 Human SwissProt: P50148 Human SwissProt: P21279 Mouse SwissProt: Q2PKF4 Pig SwissProt: P82471 Rat Unigene: 269782 Human Unigene: 439701 Mouse Unigene: 441601 Mouse Unigene: 22817 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Gαq是G蛋白家族成员之一,是Gq蛋白的功能单位。其功能为传导来自GPCR的信号到细胞内。研究证明,Gαq与免疫细胞活化、增殖、死亡、分化、迁移,细胞因子分泌以及自身免疫等均有非常密切的关系。