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MAS1癌基因抗体
  • 产品货号：
    BN41178R
  • 中文名称：
    MAS1癌基因抗体
  • 英文名称：
    Rabbit anti-MAS1 Polyclonal antibody

  • 货号

    产品规格

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  • BN41178R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推荐应用：IHC-P,Flow-Cyt,ELISA

  • BN41178R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推荐应用：IHC-P,Flow-Cyt,ELISA

英文名称MAS1
中文名称MAS1癌基因抗体
别    名Mas-related G protein-coupled receptor A; MAS1 oncogene; MAS; MGRA; MAS_HUMAN. 


研究领域肿瘤  免疫学  信号转导  生长因子和激素  细胞周期蛋白  转录调节因子  细胞表面分子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MAS1:51-150/325 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP binding proteins and share a conserved structural motif, which is described as a '7 transmembrane segment' following the prediction that these hydrophobic segments form membrane spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth regulating pathway to bring about oncogenic effects.

Function:
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Subunit:
Interacts with AGTR1 (Probable).

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P04201

Gene ID:
4142

Database links:

Entrez Gene: 4142 Human

Omim: 165180 Human

SwissProt: P04201 Human

Unigene: 99900 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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