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激肽释放酶抑制剂抗体
  • 产品货号：
    BN41169R
  • 中文名称：
    激肽释放酶抑制剂抗体
  • 英文名称：
    Rabbit anti-KLST/Kallistatin Polyclonal antibody

  • 货号

    产品规格

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  • BN41169R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41169R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称KLST/Kallistatin
中文名称激肽释放酶抑制剂抗体
别    名Serpin peptidase inhibitor clade A member 4; Kallikrein binding protein; Kallikrein inhibitor; Protease inhibitor 4; Serpin A4; KAL; Kallikrein binding protein; Kallikrein inhibitor; KBP; KLST; KST; MGC108582; PI4; Protease inhibitor 4; Serpin A4; Serpin peptidase inhibitor clade A member 4; SERPINA4; KAIN_HUMAN.  


研究领域心血管  细胞生物  免疫学  生长因子和激素  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KLST/Kallistatin:151-250/427 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its amidolytic and kininogenase activity. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.

Function:
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Subunit:
Monomer and some homodimers.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the serpin family.

SWISS:
P29622

Gene ID:
5267

Database links:

Entrez Gene: 5267 Human

Omim: 147935 Human

SwissProt: P29622 Human

Unigene: 719893 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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