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组蛋白去乙酰化酶8抗体
  • 产品货号：
    BN40836R
  • 中文名称：
    组蛋白去乙酰化酶8抗体
  • 英文名称：
    Rabbit anti-HDAC8 Polyclonal antibody

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    产品规格

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  • BN40836R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN40836R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称HDAC8
中文名称组蛋白去乙酰化酶8抗体
别    名HD 8; HD8; HDAC 8; HDACL 1; HDACL1; Histone deacetylase 8; Histone deacetylase like 1; RPD 3; RPD3; CDA07; Hdac8; HDAC8_HUMAN.  
研究领域肿瘤  发育生物学  信号转导  细胞凋亡  转录调节因子  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HDAC8:151-250/377 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.

Subunit:
Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).

Subcellular Location:
Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Tissue Specificity:
Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.

Post-translational modifications:
Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

SWISS:
Q9BY41

Gene ID:
55869

Database links:

Entrez Gene: 55869 Human

Entrez Gene: 70315 Mouse

Entrez Gene: 363481 Rat

Omim: 300269 Human

SwissProt: Q9BY41 Human

SwissProt: Q8VH37 Mouse

SwissProt: B1WC68 Rat

Unigene: 310536 Human

Unigene: 328128 Mouse

Unigene: 208476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.





















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