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β-酪蛋白抗体
  • 产品货号：
    BN40809R
  • 中文名称：
    β-酪蛋白抗体
  • 英文名称：
    Rabbit anti-Beta-casein Polyclonal antibody

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    产品规格

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  • BN40809R-100ul

    100ul

    ¥2360.00

    交叉反应：Cow,Goat(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40809R-200ul

    200ul

    ¥3490.00

    交叉反应：Cow,Goat(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称Beta-casein
中文名称β-酪蛋白抗体
别    名Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.  
研究领域细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Cow, Goat,  (predicted: Mouse, Rat, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse Beta-casein:171-231/231 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

Function:
Important role in determination of the surface properties of the casein micelles. Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. Antioxidant peptide has antioxidant activity.

Subcellular Location:
Secreted.

Tissue Specificity:
Mammary gland specific. Secreted in milk.

Similarity:
Belongs to the beta-casein family.

SWISS:
P10598

Gene ID:
12291

Database links:

Entrez Gene: 1447 Human

Entrez Gene: 281099 Bovin

Entrez Gene: 443391 Sheep

Omim: 115460 Human

SwissProt: P05814 Human

SwissProt: P02666 Bovin

Unigene: 2242 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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