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BN40775R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep) 推荐应用：WB,ELISA
BN40775R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep) 推荐应用：WB,ELISA
| 英文名称 | EAAT1 |
| 中文名称 | 胶质细胞谷氨酸运载蛋白1抗体 |
| 别 名 | EA6; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST1; Glial high affinity glutamate transporter; High affinity neuronal glutamate transporter; Slc1a3; Sodium dependent glutamate/aspartate transporter; EAA1_HUMAN. |
| 研究领域 | 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EAAT1:441-512/512 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014] Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Post-translational modifications: Glycosylated. DISEASE: Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia. Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. SWISS: P43003 Gene ID: 6507 Database links: Entrez Gene: 6507 Human Entrez Gene: 20512 Mouse Omim: 600111 Human SwissProt: P43003 Human SwissProt: P56564 Mouse Unigene: 481918 Human Unigene: 204834 Mouse Unigene: 34134 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
