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胞浆钙独立磷脂酶A2抗体
  • 产品货号：
    BN40724R
  • 中文名称：
    胞浆钙独立磷脂酶A2抗体
  • 英文名称：
    Rabbit anti-CaIPLA2 Polyclonal antibody

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  • BN40724R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF

  • BN40724R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF

英文名称CaIPLA2
中文名称胞浆钙独立磷脂酶A2抗体
别    名85 kDa calcium independent phospholipase A2; 85 kDa calcium-independent phospholipase A2; CaI PLA2; CaI-PLA2; CaIPLA2; Calcium independent phospholipase A2; Cytosolic calcium independent phospholipase A2; Group VI phospholipase A2; GVI; GVI PLA2; INAD1; iPLA(2)beta; iPLA2; IPLA2 VIA; iPLA2beta; NBIA2A; NBIA2B; PA2G6_HUMAN; PARK14; Patatin like phospholipase domain containing 9; Patatin like phospholipase domain containing protein 9; Phospholipase A2 calcium independent; Phospholipase A2 calcium independent group VI A; Phospholipase A2 group VI; Phospholipase A2 group VI cytosolic calcium independent; PLA2; PLA2G6; PNPLA9; PLPL9_HUMAN  
研究领域信号转导  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量90kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CaIPLA2:331-430/806 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].

Function:
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Subunit:
Forms large oligomeric 270-350 kDa structures.

Subcellular Location:
Isoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Isoform SH-iPLA2: Cytoplasm.

Tissue Specificity:
Four different transcripts were found to be expressed in a distinct tissue distribution.

DISEASE:
Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2B (NBIA2B) [MIM:610217]. A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment.
Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2A (NBIA2A) [MIM:256600]; also known as Seitelberger disease. NBIA2A is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years.
Defects in PLA2G6 are the cause of Parkinson disease type 14 (PARK14) [MIM:612953]. An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging.

Similarity:
Contains 7 ANK repeats.
Contains 1 patatin domain.

SWISS:
O60733

Gene ID:
8398

Database links:

Entrez Gene: 8398 Human

Entrez Gene: 53357 Mouse

Entrez Gene: 360426 Rat

Omim: 603604 Human

SwissProt: O60733 Human

SwissProt: P97819 Mouse

SwissProt: P97570 Rat

Unigene: 170479 Human

Unigene: 155620 Mouse

Unigene: 44692 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.