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PEG3蛋白抗体
  • 产品货号：
    BN40717R
  • 中文名称：
    PEG3蛋白抗体
  • 英文名称：
    Rabbit anti-PEG3 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40717R-100ul

    100ul

    ¥2360.00

    交叉反应：Human 推荐应用：IHC-P

  • BN40717R-200ul

    200ul

    ¥3490.00

    交叉反应：Human 推荐应用：IHC-P

英文名称PEG3
中文名称PEG3蛋白抗体
别    名Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24; Kruppel-type zinc finger protein; paternally expressed 3; Paternally expressed gene 3; PEG3 protein; Pw1; Zn-finger protein Pw1; PEG3_HUMAN; Paternally-expressed gene 3 protein.  
研究领域肿瘤  细胞生物  神经生物学  信号转导  细胞周期蛋白  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, 
产品应用IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量175kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PEG3:1011-1110/1588 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Function:
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.

Subunit:
Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 12 C2H2-type zinc fingers.
Contains 1 SCAN box domain.

SWISS:
Q9GZU2

Gene ID:
18616

Database links:

Entrez Gene: 18616 Mouse

Entrez Gene: 66549 Mouse

Entrez Gene: 246361 Rat

SwissProt: O54978 Mouse

SwissProt: Q3URU2 Mouse

SwissProt: Q61138 Mouse

SwissProt: Q6GQS0 Mouse

SwissProt: Q8R5N0 Mouse

SwissProt: Q9QX53 Mouse

Unigene: 7952 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PEG3蛋白是一种转录因子。在胰腺、脑组织、胎盘、卵巢、睾丸等组织中表达，PEG3蛋白位于细胞核内。PEG3也是一个凋亡促进因子并可能参与调节肿瘤坏死因子(TNF)信号传导通路。


















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