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锌转运体8蛋白抗体
  • 产品货号：
    BN40708R
  • 中文名称：
    锌转运体8蛋白抗体
  • 英文名称：
    Rabbit anti-ZNT8 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40708R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat(predicted:Human,Mouse) 推荐应用：IHC-P

  • BN40708R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat(predicted:Human,Mouse) 推荐应用：IHC-P

英文名称ZNT8
中文名称锌转运体8蛋白抗体
别    名SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8; ZNT 8; ZNT8_HUMAN.  
研究领域细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Human, Mouse, )
产品应用IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ZNT8:1-100/369 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍ZNT8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].

Function:
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells

Subunit:
Homodimer (By similarity).

Subcellular Location:
Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory granules (By similarity).

Tissue Specificity:
In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.

Similarity:
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.

SWISS:
Q8IWU4

Gene ID:
169026

Database links:

Entrez Gene: 169026 Human

Omim: 611145 Human

SwissProt: Q8IWU4 Human

Unigene: 532270 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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