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环指蛋白105抗体
  • 产品货号：
    BN40695R
  • 中文名称：
    环指蛋白105抗体
  • 英文名称：
    Rabbit anti-RNF105 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40695R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human) 推荐应用：IHC-P

  • BN40695R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human) 推荐应用：IHC-P

英文名称RNF105
中文名称环指蛋白105抗体
别    名DCRR1; E3 ubiquitin protein ligase TTC3; E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105;Tetratricopeptide repeat protein 3 (TPR repeat protein D); Tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRD; TPRDI; TPRDII; TPRDIII; TTC3; TTC3_HUMAN.  
研究领域细胞生物  神经生物学  信号转导  G蛋白信号  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, )
产品应用IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量230kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF105:251-350/2025 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

Subunit:
Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.

Subcellular Location:
Nucleus.

Tissue Specificity:
Found in all tissues examined.

Post-translational modifications:
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.

Similarity:
Contains 1 RING-type zinc finger.
Contains 4 TPR repeats.

SWISS:
P53804

Gene ID:
7267

Database links:

Entrez Gene: 7267 Human

Omim: 602259 Human

SwissProt: P53804 Human

Unigene: 368214 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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