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丝氨酸/苏氨酸蛋白激酶蛋白抗体
  • 产品货号：
    BN40693R
  • 中文名称：
    丝氨酸/苏氨酸蛋白激酶蛋白抗体
  • 英文名称：
    Rabbit anti-Haspin Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40693R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human) 推荐应用：WB

  • BN40693R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human) 推荐应用：WB

英文名称Haspin
中文名称丝氨酸/苏氨酸蛋白激酶蛋白抗体
别    名germ cell associated 2; Germ cell-specific gene 2 protein; GSG2; H-Haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase Haspin.  


研究领域染色质和核信号  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, )
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse Haspin:421-520/754 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Haspins is a protein family containing a distinctive C-terminal kinase domain and a divergent N-terminus. Haspin homologues occur within a diverse group of eukaryotes, including animals, plants and fungi, which suggests an early evolutionary origin. Haspin, a nuclear protein strongly expressed in male germ cells, is responsible for the phosphorylation of histone H3 at Thr-3. Depletion of Haspin RNA prevents normal alignment of chromosomes at metaphase, suggesting a crucial role for haspin during chromosome segregation. Expression of haspin also occurs in adult thymus and bone marrow, with weaker expression in adult prostate, intestine, lung, spleen, and lymph node. The gene encoding human haspin maps to chromosome 17p13.

Function:
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Subcellular Location:
Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.

Tissue Specificity:
Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.

Post-translational modifications:
Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
Contains 1 protein kinase domain.

SWISS:
Q9Z0R0

Gene ID:
14841

Database links:

Entrez Gene: 83903 Human

Omim: 609240 Human

SwissProt: Q8TF76 Human

Unigene: 534059 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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