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驱动蛋白家族成员18B抗体
  • 产品货号：
    BN40692R
  • 中文名称：
    驱动蛋白家族成员18B抗体
  • 英文名称：
    Rabbit anti-KIF18B Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40692R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat(predicted:Human,Mouse,Dog,Cow,Horse,Sheep) 推荐应用：IHC-P

  • BN40692R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat(predicted:Human,Mouse,Dog,Cow,Horse,Sheep) 推荐应用：IHC-P

英文名称KIF18B
中文名称驱动蛋白家族成员18B抗体
别    名Kinesin family member 18B; KI18B_HUMAN; Kinesin-like protein KIF18B.  
研究领域细胞生物  信号转导  细胞分化  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, Sheep, )
产品应用IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量94kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KIF18B :121-220/864 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The Kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual Kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events, including endocytosis and transcytosis. KIF18B (kinesin family member 18B) is an 864 amino acid nuclear and cytoplasmic protein that belongs to the kinesin-like protein family. Containing one kinesin-motor domain, KIF18B is dominantly expressed in amygdala. During mitosis, KIF18B is suggested to be closely associated with astral microtubules emanating from the spindle pole during prometaphase and metaphase. KIF18B may play an important role in regulating cell division. KIF18B exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.31.

Function:
May play an important role in regulating cell division.

Subunit:
Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.

Subcellular Location:
Cytoplasmic, Nuclear and Plasma membrane

Tissue Specificity:
Shows a prominent expression in the amygdala.

Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.

SWISS:
Q86Y91

Gene ID:
146909

Database links:

Entrez Gene: 146909 Human

Omim: 614570 Human

SwissProt: Q86Y91 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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