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鳞状细胞癌增强蛋白1抗体
  • 产品货号：
    BN40684R
  • 中文名称：
    鳞状细胞癌增强蛋白1抗体
  • 英文名称：
    Rabbit anti-GASC1/KDM4C Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40684R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

  • BN40684R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,ELISA

英文名称GASC1/KDM4C
中文名称鳞状细胞癌增强蛋白1抗体
别    名GASC 1 protein; GASC1 antibody Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; Jumonji domain containing protein 2C; KDM4C_HUMAN.  
研究领域肿瘤  免疫学  染色质和核信号  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:500-5000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量120kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GASC1/KDM4C:291-390/1056 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍KDM4C/JMJD2C, a jumonji domain containing protein, is a histone demethylase. JMJD2C specifically demethylates Lysine 9 and Lysine 36 residues of Histone H3, thereby playing a central role in regulating histone modifications.

Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Subcellular Location:
Nucleus.

Tissue Specificity:
Overexpressed in several esophageal squamous cell carcinomas (ESCs).

Similarity:
Belongs to the JHDM3 histone demethylase family.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
Contains 2 PHD-type zinc fingers.
Contains 2 Tudor domains.

SWISS:
Q9H3R0

Gene ID:
23081

Database links:

Entrez Gene: 23081 Human

Entrez Gene: 76804 Mouse

Entrez Gene: 298144 Rat

Omim: 605469 Human

SwissProt: Q9H3R0 Human

SwissProt: Q8VCD7 Mouse

Unigene: 709425 Human

Unigene: 209059 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.











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