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单羧酸转运蛋白2抗体
  • 产品货号：
    BN40682R
  • 中文名称：
    单羧酸转运蛋白2抗体
  • 英文名称：
    Rabbit anti-MCT2 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40682R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat 推荐应用：WB,ELISA

  • BN40682R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat 推荐应用：WB,ELISA

英文名称MCT2
中文名称单羧酸转运蛋白2抗体
别    名MCT 2; MCT; Monocarboxylate transporter 2; MonocarboxylateTransporter 2; MOT2; MOT2_HUMAN; SLC16A7; Solute carrier family 16 member 7; Solute carrier Family 16 Monocarboxylic Acid Transporters Member 7.  
研究领域肿瘤  细胞生物  免疫学  信号转导  转运蛋白  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse MCT2 :411-478/478 <Cytoplasmic>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Tissues with few or no mitochondria, such as erythrocytes and tumor cells, depend largely on glycolysis to generate ATP. The major end products of glycolysis, pyruvate and lactate, must be eliminated from these cells to enable continued glycolytic flux and prevent toxic effects. H+/monocarboxylate transporters (MCTs) mediate the transport of lactate and pyruvate. Human MCT2 has a high affinity for the transport of pyruvate (summary by Lin et al., 1998 [PubMed 9786900]).[supplied by OMIM, Feb 2011].

Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter.

Subunit:
Interacts with GRID2IP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.

Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

SWISS:
O70451

Gene ID:
20503

Database links:

Entrez Gene: 9194 Human

Omim: 603654 Human

SwissProt: O60669 Human

Unigene: 439643 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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