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程序性死亡配体1抗体
  • 产品货号：
    BN40675R
  • 中文名称：
    程序性死亡配体1抗体
  • 英文名称：
    Rabbit anti-PD-L1 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40675R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,Flow-Cyt

  • BN40675R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,Flow-Cyt

英文名称PD-L1
中文名称程序性死亡配体1抗体
别    名CD274; B7 H; B7 H1; B7 homolog 1; B7-H1; B7H; B7H1; CD 274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; OTTHUMP00000021029; PD L1; PD1L1_HUMAN; PD1L1_Mouse; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL 1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1; RGD1566211.  
研究领域肿瘤  细胞生物  信号转导  细胞凋亡  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Rat, )
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse PD-L1:31-130/290 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Programmed cell death 1 ligand 1(Programmed death ligand 1；PD-L1; PDCD1 ligand 1; B7 homolog 1; B7-H1; CD274) involved in the costimulatory signal, essential for T lymphocyte proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibit T-cell proliferation and cytokine production.

Function:
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Subunit:
Interacts with PDCD1.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q9EP73

Gene ID:
60533

Database links:

Entrez Gene: 29126 Human

Entrez Gene: 60533 Mouse

Entrez Gene: 499342 Rat

Omim: 605402 Human

SwissProt: Q9NZQ7 Human

SwissProt: Q9EP73 Mouse

Unigene: 521989 Human

Unigene: 245363 Mouse

Unigene: 228198 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

程序性死亡配体1（B7-H1）可以促进上皮细胞的恶性转化,保护表皮细胞免于失巢凋亡,在肿瘤的发生,进展和转归中发挥重要作用.
目前对CD274信号通路的进一步的研究必将为自身免疫性疾病、病毒感染性疾病和器官移植后排斥反应中T细胞介导的免疫应答调控提供了新的途径.B7-H1在癌症、类风湿、HIV感染等疾病中发现B7-H1有负调节作用。对B7-H1路径进行调控有助于自身免疫病及恶性肿瘤的治疗。

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