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褪黑素受体1A/松果体素受体1A抗体
  • 产品货号：
    BN40670R
  • 中文名称：
    褪黑素受体1A/松果体素受体1A抗体
  • 英文名称：
    Rabbit anti-Melatonin Receptor 1A Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40670R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat,Cow,Sheep) 推荐应用：WB,Flow-Cyt,ELISA

  • BN40670R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat,Cow,Sheep) 推荐应用：WB,Flow-Cyt,ELISA

英文名称Melatonin Receptor 1A
中文名称褪黑素受体1A/松果体素受体1A抗体
别    名Mel 1A R; Mel1a melatonin receptor; Mel1a receptor; MEL-1A-R; Melatonin receptor type 1A; MelR; MR; MT 1; MT1; MTNR 1A; MTNR1A; Melatonin receptor 1A; MTR1A_HUMAN; MTR-1A.  
研究领域肿瘤  细胞生物  神经生物学  信号转导  细胞膜受体  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Cow, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Melatonin Receptor 1A :181-280/350 <Cytoplasmic>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P48039

Gene ID:
4543

Database links:
Entrez Gene: 4543 Human

Omim: 600665 Human

SwissProt: P48039 Human

Unigene: 243467 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

褪黑激素受体1A- 此抗体是MTR-1A特异性抗体，与MTR-1B无交叉反应。MEL-1A-R除分布在视网膜和下丘脑外，还广泛存在于多个组织中，也是有重着要生理活性的激素。
















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