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BN40629R-100ul
100ul
¥2360.00
交叉反应：Mouse,Rat(predicted:Human,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
BN40629R-200ul
200ul
¥3490.00
交叉反应：Mouse,Rat(predicted:Human,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
| 英文名称 | beta-Synuclein |
| 中文名称 | 核突触蛋白-β抗体 |
| 别 名 | 14 kDa brain-specific protein; Beta-synuclein; Phosphoneuroprotein 14; PNP14; Sncb; Synuclein beta; SYUB_HUMAN; |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Cow, Rabbit, Sheep, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human beta-Synuclein :51-100/140 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] Function: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. Subcellular Location: Cytoplasm Tissue Specificity: Expressed predominantly in brain; concentrated in presynaptic nerve terminals. Post-translational modifications: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. Similarity: Belongs to the synuclein family. SWISS: Q16143 Gene ID: 6620 Database links: Entrez Gene: 6620 Human Entrez Gene: 104069 Mouse Omim: 602569 Human SwissProt: Q16143 Human SwissProt: Q91ZZ3 Mouse Unigene: 90297 Human Unigene: 200843 Mouse Unigene: 20352 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
