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SAPS结构域家族1抗体
  • 产品货号：
    BN40555R
  • 中文名称：
    SAPS结构域家族1抗体
  • 英文名称：
    Rabbit anti-SAPS1 Polyclonal antibody

  • 货号

    产品规格

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  • BN40555R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Rhesus monkey, Gorilla, Orangutan) 推荐应用：WB

  • BN40555R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Rhesus monkey, Gorilla, Orangutan) 推荐应用：WB

英文名称SAPS1
中文名称SAPS结构域家族1抗体
别    名PP6R1; Protein phosphatase 6, regulatory subunit 1; SAP190; SAPS domain family, member 1.  
研究领域细胞生物  信号转导  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Rhesus monkey, Gorilla, Orangutan)
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量97kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SAPS1:31-130/881 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Function:
Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

Subunit:
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.

Subcellular Location:
Cytoplasm

Tissue Specificity:
Ubiquitous with higher expression in testis.

Similarity:
Belongs to the SAPS family.

SWISS:
Q9UPN7

Gene ID:
22870

Database links:

Entrez Gene: 22870 Human

Omim: 610875 Human

SwissProt: Q9UPN7 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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