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磷酸化c-mer原癌基因酪氨酸激酶抗体
  • 产品货号：
    BN40538R
  • 中文名称：
    磷酸化c-mer原癌基因酪氨酸激酶抗体
  • 英文名称：
    Rabbit anti-phospho-MERTK (Tyr749) Polyclonal antibody

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  • BN40538R-100ul

    100ul

    ¥2470.00

    交叉反应：nan(predicted:Human,Mouse,Rat) 推荐应用：ELISA

英文名称phospho-MERTK (Tyr749)
中文名称磷酸化c-mer原癌基因酪氨酸激酶抗体
别    名MERTK (phospho Y749); p-MERTK (phospho Y749); c MER; c mer proto oncogene tyrosine kinase; c-mer; cMER; cmer protooncogene tyrosine kinase; Eyk; MER; MER receptor tyrosine kinase; MERK; MERPEN; Mertk; MERTK c-mer proto-oncogene tyrosine kinase; MERTK_HUMAN; MGC133349; nmf12; Nyk; Proto oncogene tyrosine protein kinase MER; Proto oncogene tyrosine protein kinase MER precursor; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; RP38; STK kinase; Tyrosine-protein kinase Mer.  
产品类型磷酸化抗体 
研究领域细胞生物  神经生物学  信号转导  激酶和磷酸酶  t-淋巴细胞  b-淋巴细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应(predicted: Human, Mouse, Rat, )
产品应用ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human MERTK around the phosphorylation site of Tyr749:KI(p-Y)SG 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

Function:
In case of filovirus infection, seems to function as a cell entry factor.

Subcellular Location:
Membrane.

Tissue Specificity:
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.

DISEASE:
Defects in MERTK are the cause of retinitis pigmentosa type 38 (RP38) [MIM:613862]. RP38 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

SWISS:
Q12866

Gene ID:
10461

Database links:

Entrez Gene: 10461 Human

Omim: 604705 Human

SwissProt: Q12866 Human

Unigene: 306178 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.