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胰岛素样生长因子2mRNA结合蛋白3抗体
  • 产品货号：
    BN40477R
  • 中文名称：
    胰岛素样生长因子2mRNA结合蛋白3抗体
  • 英文名称：
    Rabbit anti-IMP3 Polyclonal antibody

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    产品规格

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  • BN40477R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40477R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称IMP3
中文名称胰岛素样生长因子2mRNA结合蛋白3抗体
别    名Cancer/testis antigen 98; CT98; DKFZp686F1078; hKOC; IF2B3_HUMAN; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA binding protein 3; IGF2 mRNA-binding protein 3; IGF2BP3; IMP 3; IMP-3; Insulin like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC 1; KOC1; VICKZ 3; VICKZ family member 3; VICKZ3.  
研究领域肿瘤  细胞生物  信号转导  结合蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量64kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IMP3:21-100/579 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Function:
RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.

Subcellular Location:
Nucleus. Cytoplasm. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

Tissue Specificity:
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

Similarity:
Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.

SWISS:
O00425

Gene ID:
10643

Database links:

Entrez Gene: 10643 Human

Entrez Gene: 140488 Mouse

Entrez Gene: 312320 Rat

Omim: 608259 Human

SwissProt: O00425 Human

SwissProt: Q9CPN8 Mouse

Unigene: 700696 Human

Unigene: 281018 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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