货号
产品规格
售价
备注
BN40461R-100ul
100ul
¥2360.00
交叉反应：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
BN40461R-200ul
200ul
¥3490.00
交叉反应：Mouse,Rat(predicted:Human,Pig,Cow,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
| 英文名称 | COMT |
| 中文名称 | 儿茶酚O甲基移位酶抗体 |
| 别 名 | Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6. |
| 研究领域 | 神经生物学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COMT:121-220/271 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Subcellular Location: Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side. Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the mammalian catechol-O-methyltransferase family. SWISS: P21964 Gene ID: 1312 Database links: Entrez Gene: 1312 Human Entrez Gene: 12846 Mouse Omim: 116790 Human SwissProt: P21964 Human SwissProt: O88587 Mouse Unigene: 370408 Human Unigene: 704514 Human Unigene: 100940 Mouse Unigene: 220 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
