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蛋白酶调解因子9抗体
  • 产品货号：
    BN40436R
  • 中文名称：
    蛋白酶调解因子9抗体
  • 英文名称：
    Rabbit anti-PSMD9 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40436R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,GuineaPig) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN40436R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,GuineaPig) 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称PSMD9
中文名称蛋白酶调解因子9抗体
别    名Bridge-1; MGC8644; 26S proteasome non ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27; Homolog of rat Bridge 1; p27; Proteasome (prosome macropain) 26S subunit non ATPase 9; Proteasome 26S non ATPase regulatory subunit 9; Proteasome 26S subunit non ATPase 9; PSMD 9; Rpn4; PSMD9_HUMAN.   
研究领域免疫学  转录调节因子  糖尿病  内分泌病  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PSMD9:65-150/223 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Function:
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.

Subunit:
Interacts with PSMC3. Part of a transient complex (modulator) containing PSMD9, PSMC6 and PSMC3 formed during the assembly of the 26S proteasome.

Tissue Specificity:
Expressed in all tissues tested, highly expressed in liver and kidney.

Similarity:
Belongs to the proteasome subunit p27 family.
Contains 1 PDZ (DHR) domain.

SWISS:
O00233

Gene ID:
5715

Database links:

Entrez Gene: 5715 Human

Entrez Gene: 67151 Mouse

Omim: 603146 Human

SwissProt: O00233 Human

SwissProt: Q9CR00 Mouse

Unigene: 131151 Human

Unigene: 278997 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PSMD-9蛋白有可能增强激活胰岛素的产生，主要用于二型糖尿病的研究。


















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