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钙粘蛋白14抗体
  • 产品货号：
    BN40435R
  • 中文名称：
    钙粘蛋白14抗体
  • 英文名称：
    Rabbit anti-CDHF14 Polyclonal antibody

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    产品规格

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  • BN40435R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40435R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称CDHF14
中文名称钙粘蛋白14抗体
别    名Cadherin family member 14; CDHF14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; FAT4_HUMAN; FATJ; hFat4; Nbla00548; Protocadherin Fat 4.  
研究领域肿瘤  细胞生物  信号转导  细胞粘附分子  细胞类型标志物  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量538kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CDHF14:4351-4450/4981 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT4 (FAT tumor suppressor homolog 4), also known as FAT-J, CDHF14 or CDHR11, is a 4,981 amino acid single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins and localizes to the primary cilia of kidney. Widely expressed, FAT4 contains thirty-four cadherin domains, six EGF-like domains and two laminin G-like domains. FAT4 may function in the regulation of planar cell polarity.

Function:
May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules.

Subcellular Location:
Membrane. In the kidney, localizes to primary cilia.

Tissue Specificity:
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.

Similarity:
Contains 34 cadherin domains.
Contains 6 EGF-like domains.
Contains 2 laminin G-like domains.

SWISS:
Q6V0I7

Gene ID:
79633

Database links:

Entrez Gene: 79633 Human

SwissProt: Q6V0I7 Human

Unigene: 563205 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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