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磷酸化淋巴细胞胞浆蛋白2抗体
  • 产品货号：
    BN40433R
  • 中文名称：
    磷酸化淋巴细胞胞浆蛋白2抗体
  • 英文名称：
    Rabbit anti-phospho-SLP76 (Tyr113) Polyclonal antibody

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  • BN40433R-100ul

    100ul

    ¥2470.00

    交叉反应：Human,Mouse(predicted:Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,ELISA

英文名称phospho-SLP76 (Tyr113)
中文名称磷酸化淋巴细胞胞浆蛋白2抗体
别    名SLP76 (phospho Y113); p-SLP76 (Y113); p-LCP2; 76 kDa tyrosine phosphoprotein; CG8697; LCP 2; LCP 2; LCP2; LCP2_HUMAN; Lymphocyte Cytosolic Protein 2; Lymphocyte Cytosolic Protein 2; SH2 Domain Containing Leukocyte Protein 76 KD; SH2 domain containing leukocyte protein of 76kD; SH2 domain containing leukocyte protein of 76kDa; SH2 domain-containing leukocyte protein of 76 kDa; SLP 76; SLP 76; SLP 76 tyrosine phosphoprotein; SLP-76 tyrosine phosphoprotein; SLP76; SLP76 tyrosine phosphoprotein.  
产品类型磷酸化抗体 
研究领域细胞生物  信号转导  激酶和磷酸酶  淋巴细胞  t-淋巴细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量75kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human SLP76 around the phosphorylation site of Tyr113:DD(p-Y)ES 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.

Function:
Involved in T-cell antigen receptor mediated signaling.

Subunit:
Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. Post-translational modifications : Phosphorylated after T-cell receptor activation by ZAP-70.

Similarity:
Contains 1 SAM (sterile alpha motif) domain.
Contains 1 SH2 domain.

SWISS:
Q13094

Gene ID:
3937

Database links:

Entrez Gene: 3937 Human

Omim: 601603 Human

SwissProt: Q13094 Human

Unigene: 304475 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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