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G蛋白偶联受体43抗体
  • 产品货号：
    BN40427R
  • 中文名称：
    G蛋白偶联受体43抗体
  • 英文名称：
    Rabbit anti-GPR43 Polyclonal antibody

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    产品规格

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  • BN40427R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Human(predicted:Rat) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40427R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Human(predicted:Rat) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

英文名称GPR43
中文名称G蛋白偶联受体43抗体
别    名GPCR GPR43; FFA2R; Ffar2; FFAR2_HUMAN; free fatty acid activated receptor 2; Free fatty acid receptor 2; G protein coupled receptor 43; G protein-coupled receptor 43; G-protein coupled receptor 43; GPR 43; GPCR 43. 


研究领域细胞生物  信号转导  G蛋白偶联受体  G蛋白信号  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GPR43:41-140/330 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor (GPR) GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. GPR43 functions as a ligand for short chain fatty acids (SCFAs), notably acetate and propionate. Bacteria in the gut produce high concentrations of SCFAs, which are subsequently released in the bloodstream, where they exert cellular effects on blood leukocytes, including calcium release, ERK1/2 activation, and inhibition of cAMP accumulation. These effects indicate a role for GPR43 in the recruitment of leukocytes, particularly polymorphonuclear cells, to sites of bacterial infection.

Function:
Receptor for short chain fatty acids through a G(i)-protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed at relatively high levels in peripheral blood leukocytes and, to lesser, extent, in spleen.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
O15552

Gene ID:
2867

Database links:

Entrez Gene: 2867 Human

Omim: 603823 Human

SwissProt: O15552 Human

Unigene: 248056 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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