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谷胱甘肽过氧化酶7抗体
  • 产品货号：
    BN40421R
  • 中文名称：
    谷胱甘肽过氧化酶7抗体
  • 英文名称：
    Rabbit anti-GPX7 Polyclonal antibody

  • 货号

    产品规格

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  • BN40421R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Chicken,Cow,Rabbit,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40421R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Chicken,Cow,Rabbit,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称GPX7
中文名称谷胱甘肽过氧化酶7抗体
别    名CL683; FLJ14777; Glutathione peroxidase 7; GPx-7; GPX6; GPX7; GPX7_HUMAN; GSHPx-7; NPGPx.  
研究领域细胞生物  信号转导  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Chicken, Cow, Rabbit, Monkey, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GPX7/Glutathione Peroxidase 7:11-110/187 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-7 (glutathione peroxidase 7), also known as GPX6, CL683 or NPGPx, is a 187 amino acid secreted protein belonging to the glutathione peroxidase family. GPx-7 catalyzes the reaction of glutathione into glutathione disulfide and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

DISEASE:
Defects in GPX7 are a cause of Barrett esophagus (BE) [MIM:614266]. A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Similarity:
Belongs to the glutathione peroxidase family.

SWISS:
Q96SL4

Gene ID:
2882

Database links:

Entrez Gene: 2882 Human

Entrez Gene: 67305 Mouse

Entrez Gene: 298376 Rat

SwissProt: A6QLY2 Cow

SwissProt: Q96SL4 Human

SwissProt: Q99LJ6 Mouse

Unigene: 43728 Human

Unigene: 20164 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications






















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