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胰岛葡萄糖6磷酸酶2抗体
  • 产品货号：
    BN40420R
  • 中文名称：
    胰岛葡萄糖6磷酸酶2抗体
  • 英文名称：
    Rabbit anti-Glucose 6 phosphatase 2 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40420R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat(predicted:Human,Mouse,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,ELISA

  • BN40420R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat(predicted:Human,Mouse,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,ELISA

英文名称Glucose 6 phosphatase 2
中文名称胰岛葡萄糖6磷酸酶2抗体
别    名G 6 Pase 2; G 6 Pase2; G6Pase 2; G6Pase2; G6PC 2; G6pc rs; G6pcrs; Glucose 6 phosphatase 2; Glucose 6 phosphatase, catalytic, 2; Glucose 6 phosphatase, catalytic, related; Glucose 6 phosphate catalytic 2; Islet specific G6CP related protein; Islet specific glucose 6 phosphatase; Islet specific glucose 6 phosphatase catalytic subunit related protein; G6PC2_HUMAN.  
研究领域肿瘤  细胞生物  信号转导  激酶和磷酸酶  糖尿病  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Human, Mouse, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2/IGRP:31-130/355 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.

Function:
IGRP (islet specific glucose 6 phosphatase catalytic subunit related protein), also known as G6PC2, belongs to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyses the hydrolysis of glucose-6-phosphate. This hydrolysis is the terminal step in gluconeogenic and glycogenolytic pathways, and allows the release of glucose into the bloodstream. IGRP is found in pancreatic islets and does not exhibit phosphohydrolase activity. However, it is a major target of cell-mediated autoimmunity in diabetes.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Specifically expressed in pancreas and also detected to a lower extent in testis. Expressed by most islet cells in the pancreas (at protein level).

Post-translational modifications:
N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome.

Similarity:
Belongs to the glucose-6-phosphatase family.

SWISS:
Q9NQR9

Gene ID:
57818

Database links:




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.





















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