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GTP结合丝裂原诱导T细胞蛋白抗体
  • 产品货号：
    BN40418R
  • 中文名称：
    GTP结合丝裂原诱导T细胞蛋白抗体
  • 英文名称：
    Rabbit anti-GEM Polyclonal antibody

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    产品规格

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  • BN40418R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40418R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称GEM
中文名称GTP结合丝裂原诱导T细胞蛋白抗体
别    名GTP binding mitogen induced T cell protein; GTP binding protein expressed in mitogen stimulated T cells; GTP binding protein GEM; GTP binding protein overexpressed in skeletal muscle; Kinase inducible Ras like protein; KIR; MGC26294; RAS like protein KIR; GEM_HUMAN.  
研究领域细胞生物  信号转导  G蛋白偶联受体  淋巴细胞  t-淋巴细胞  G蛋白信号  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GEM:201-296/296 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which lack typical C-terminal amino acid motifs for isoprenylation. Rad and Gem bind calmodulin in a Ca2+-dependent manner via this C-terminal extension, involving residues 278–297 in human Rad. High intracellular Gem levels, which interact with intact microtubules and microfilaments, promote profound changes in cell morphology. Ectopic Gem expression is sufficient to stimulate cell flattening and neurite extension in N1E-115 and SH-SY5Y neuroblastoma cells, suggesting a role for Gem in cytoskeletal rearrangement and/or morphological differentiation of neurons. Gem was also observed in developing trigeminal nerve ganglia in 12.5 day mouse embryos, demonstrating that Gem expression is a property of normal ganglionic development. The interaction of Gem with beta-subunits regulates Ca2+ channel expression at the cell surface. The human Gem gene maps to chromosome 8q22.1.

Function:
GEM belongs to the RAD/GEM family of GTP-binding proteins. It could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. GEM has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Subunit:
Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.

Post-translational modifications:
Phosphorylated on tyrosine residues.

Similarity:
Belongs to the small GTPase superfamily. RGK family.

SWISS:
P55040

Gene ID:
2669

Database links:

Entrez Gene: 2669 Human

Entrez Gene: 14579 Mouse

Entrez Gene: 297902 Rat

Omim: 600164 Human

SwissProt: P55040 Human

SwissProt: P55041 Mouse

Unigene: 654463 Human

Unigene: 247486 Mouse

Unigene: 40436 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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