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叉头蛋白H1抗体
  • 产品货号：
    BN40414R
  • 中文名称：
    叉头蛋白H1抗体
  • 英文名称：
    Rabbit anti-FOXH1 Polyclonal antibody

  • 货号

    产品规格

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  • BN40414R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep) 推荐应用：WB,ELISA

  • BN40414R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Sheep) 推荐应用：WB,ELISA

英文名称FOXH1
中文名称叉头蛋白H1抗体
别    名FAST 1; Fast 2; Fast-1; Fast-2; FAST1; Fast2; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; Forkhead box H1; Forkhead box protein H1; FOX H1; FOXH 1; FOXH1; FOXH1_HUMAN; hFAST 1; hFAST-1; hFAST1; Human homolog of Xenopus forkhead activin signal transducer 1; TGF beta/Activin signal transducer FAST1.  
研究领域肿瘤  细胞生物  发育生物学  信号转导  转录调节因子  细胞分化  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FOXH1:41-140/365 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFG?and activin, indicating that these FAST proteins mediate TFG?induced signal transduction (3).

Function:
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

Subunit:
Interacts with the MH2 domains of SMAD2 and SMAD3.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous.

Similarity:
Contains 1 fork-head DNA-binding domain.

SWISS:
O75593

Gene ID:
8928

Database links:

Entrez Gene: 8928 Human

Omim: 603621 Human

SwissProt: O75593 Human

Unigene: 708365 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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