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BN40412R-100ul
100ul
¥2360.00
交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40412R-200ul
200ul
¥3490.00
交叉反应：Human,Rat(predicted:Mouse,Dog,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
| 英文名称 | FMN1 |
| 中文名称 | 肢体畸形相关蛋白FMN1抗体 |
| 别 名 | FMN; Formin 1; Formin1; Formin-1; LD; Limb deformity protein homolog; FMN1_HUMAN. |
| 研究领域 | 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, (predicted: Mouse, Dog, Cow, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 157kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FMN1/Formin 1:651-750/1419 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively. Function: FMN1 plays a role in the formation of adherens junction and the polymerization of linear actin cables. Interacts with alpha-catenin and may interact with tubulin. Subunit: Interacts with alpha-catenin and may interact with tubulin (By similarity). Subcellular Location: Nucleus. Cytoplasm. Cell junction, adherens junction; Peripheral membrane protein; Cytoplasmic side. Post-translational modifications: Phosphorylated on serine and possibly threonine residues (By similarity). Similarity: Belongs to the formin homology family. Cappuccino subfamily. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. SWISS: Q68DA7 Gene ID: 342184 Database links: Entrez Gene: 342184 Human Entrez Gene: 14260 Mouse Omim: 136535 Human SwissProt: Q68DA7 Human SwissProt: Q05860 Mouse Unigene: 657649 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
