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F-box蛋白2抗体
  • 产品货号：
    BN40408R
  • 中文名称：
    F-box蛋白2抗体
  • 英文名称：
    Rabbit anti-FBXO2 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40408R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40408R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称FBXO2
中文名称F-box蛋白2抗体
别    名F box gene 1; F box only protein 2; F box protein 2; F box protein only 2; F-box only protein 2; FBG 1; FBG1; Fbs 1; Fbs1; Fbs2; FBX 2; FBX2; FBX2_HUMAN; FBXO 2; FBXO2; Neural F box protein NFB42; Neural F-box protein, 42-KD, rat, homolog of; NFB 42; NFB42; OCP1; Prpl4.  
研究领域细胞生物  信号转导  细胞周期蛋白  泛素  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FBXO2:121-220/296 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍FBXO2 is a 296 amino acid protein that contains one F-box domain and one F-box associated domain. Functioning as a component of the SCF complex, FBXO2 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation.

Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.

Subunit:
Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).

Subcellular Location:
Cytoplasm. Microsome membrane.

Similarity:
Contains 1 F-box domain.
Contains 1 FBA (F-box associated) domain.

SWISS:
Q9UK22

Gene ID:
26232

Database links:

Entrez Gene: 26232 Human

Entrez Gene: 230904 Mouse

Entrez Gene: 85273 Rat

Omim: 607112 Human

SwissProt: Q9UK22 Human

SwissProt: Q80UW2 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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