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双特异性蛋白磷酸酶10抗体
  • 产品货号：
    BN40403R
  • 中文名称：
    双特异性蛋白磷酸酶10抗体
  • 英文名称：
    Rabbit anti-DUSP10 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN40403R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40403R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称DUSP10
中文名称双特异性蛋白磷酸酶10抗体
别    名MKP5; MKP 5; MKP-5; Dual specificity phosphatase 10; Dual specificity phosphatase MKP 5; Dual specificity phosphatase MKP5; Dual specificity protein phosphatase 10; DUS10_HUMAN; DUSP 10; DUSP10; DUSP10 protein; MAP kinase phosphatase 5; Mitogen activated protein kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; Serine/threonine specific protein phosphatase.  
研究领域细胞生物  信号转导  细胞凋亡  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human DUSP10/MKP5:161-260/482 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. MKP-5 preferentially binds to p38, but also to SAPK/JNK. It is ubiquitously expressed and localizes to both the cytoplasm and the nucleus. MKP-5 has been implicated in cell proliferation and apoptosis, tumor invasion and immune responses.

Function:
Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.

Subunit:
Monomer. Interacts with MAPK14.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Detected in brain.

Similarity:
Belongs to the protein-tyrosine phosphatase family.
Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.

SWISS:
Q9Y6W6

Gene ID:
11221

Database links:

Entrez Gene: 11221 Human

Entrez Gene: 63953 Mouse

Entrez Gene: 63995 Rat

Omim: 608867 Human

SwissProt: Q9Y6W6 Human

SwissProt: Q9ESS0 Mouse

Unigene: 497822 Human

Unigene: 404024 Mouse

Unigene: 163239 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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