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生长抑制因子基因1抗体
  • 产品货号：
    BN40399R
  • 中文名称：
    生长抑制因子基因1抗体
  • 英文名称：
    Rabbit anti-ING1 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN40399R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,ELISA

  • BN40399R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse(predicted:Human,Rat) 推荐应用：WB,ELISA

英文名称ING1
中文名称生长抑制因子基因1抗体
别    名ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; p24ING1c; p33 ING1; p33ING1; p33ING1b; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1.  
研究领域肿瘤  细胞生物  信号转导  细胞凋亡  细胞周期蛋白  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse,  (predicted: Human, Rat, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1:301-422/422 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].

Function:
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Subcellular Location:
Nucleus.

Tissue Specificity:
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

DISEASE:
Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.

Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.

SWISS:
Q9UK53

Gene ID:
3621

Database links:

Entrez Gene: 3621 Human

Entrez Gene: 26356 Mouse

Entrez Gene: 306626 Rat

GenBank: NP_937862 Human

Omim: 601566 Human

SwissProt: Q9UK53 Human

SwissProt: Q9QXV3 Mouse

Unigene: 46700 Human

Unigene: 508725 Human

Unigene: 25709 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肿瘤的发生是一个多基因参与,多步骤发生的复杂过程，抑癌基因的功能失活与癌基因的激活为其主要原因之一。 ING1基因是近期发现的抑癌基因，研究发现，它的过表达可抑制细胞生长、增殖,促进细胞凋亡，它的低表达与肿瘤的发生、发展有关。ING1正常时定位于胞核，发挥其诱导凋亡和调控细胞周期的作用，当其易位于胞质时上述作用逐步减弱或消失，在肿瘤发生时，多位于胞浆。



















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